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This interaction triggers c-Met phosphorylation and activates downstream signaling cascades including the PI3K/AKT and MAPK/ERK pathways, which are fundamental to neuronal survival, dendritic arborization, and synapse formation

These methods can work, but they are often hard to keep up over time

Titration protocols therefore hold a dose until nausea and other gastrointestinal effects settle rather than escalating on a fixed target date

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Clinical Data on Thalassemia in Kauvery hospital, Cantonment Table 1